The cell wall envelope of gram-positive bacteria is a macromolecular, exoskeletal organelle
that is assembled and turned over at designated sites. The cell wall also functions as a …

Superantigens are unconventional antigens which recognise immune receptors outside
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …

Albumin, the most abundant plasma protein, is among the most studied of all proteins, being
important from clinical monitoring, physiological, and therapeutic perspectives. This unique …

Abstract Machine learning could enable an unprecedented level of control in protein
engineering for therapeutic and industrial applications. Critical to its use in designing …

The structure of fitness landscapes is critical for understanding adaptive protein evolution.
Previous empirical studies on fitness landscapes were confined to either the neighborhood …

The high-resolution three-dimensional structure of a single immunoglobulin binding domain
(B1, which comprises 56 residues including the NH2-terminal Met) of protein G from group G …

Background: Streptococcal protein G comprises two or three domains that bind to the
constant Fc region of most mammalian immunoglobulin Gs (IgGs). Protein G is functionally …

Tandem affinity purification (TAP) is a generic two-step affinity purification protocol that
enables the isolation of protein complexes under close-to-physiological conditions for …

We are now witnessing significant progress of deep learning methods in a variety of tasks
(or datasets) of proteins. However, there is a lack of a standard benchmark to evaluate the …

We developed a knowledge-based statistical energy function for protein− ligand, protein−
protein, and protein− DNA complexes by using 19 atom types and ad istance-scale f inite i …