To cope with continuous physiological and environmental stresses, cells of all sizes require
an effective wound repair process to seal breaches to their cortex. Once a wound is …

Cytokinesis is a mechanism that separates dividing cells via constriction of a supramolecular
structure, the contractile ring. In animal cells, three modes of symmetry-breaking of …

Cell shape changes from locomotion to cytokinesis are, to a large extent, driven by myosin-
driven remodeling of cortical actin patterns. Passive crosslinkers such as α-actinin and …

Cytokinesis is the last step of cell division that partitions the cellular organelles and
cytoplasm of one cell into two. In animal cells, cytokinesis requires Rho-GTPase-dependent …

Tissue regeneration at an injured site depends on proliferation, migration, and differentiation
of resident stem or progenitor cells, but solid tissues are often sufficiently dense and …

The mechanics that govern the constriction of the contractile ring remain poorly understood
yet are critical to understanding the forces that drive cytokinesis. We used laser ablation in …

During cytokinesis cells assemble an actomyosin contractile ring whose tension constricts
and divides cells, but the ring tension was rarely measured. Actomyosin force generation is …

The actomyosin network, consisting of actin filaments and myosin motors, is essential for cell
dynamic behaviors. The sliding motion of actin filaments propelled by myosin motors is …

A fundamental challenge in cell biology is to understand how cells generate actomyosin‐
based contractile force. Here we study the actomyosin contractile ring that divides cells …

Actomyosin contractile force produced by myosin II molecules that bind and pull actin
filaments is harnessed for diverse functions, from cell division by the cytokinetic contractile …