Transforming growth factor-β (TGF-β) is a secreted homodimeric protein that plays an
important role in regulating various cellular responses including cell proliferation and …

Marfan syndrome (MFS) is a complex connective tissue disease that is primarily
characterized by cardiovascular, ocular and skeletal systems disorders. Despite its rarity …

Aberrant expression of microRNA (miR)-1 has been observed in many human malignancies.
However, the function and underlying mechanism of miR-1 remains elusive. To address the …

Transforming growth factor (TGF)-β signalling pathways are intensively investigated
because of their diverse association with physiological and pathophysiological states. Smad …

Transforming growth factor (TGF)-β1 mediates glycosaminoglycan (GAG) chain
hyperelongation on secreted proteoglycans and these modifications are associated with …

To uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer's
disease, we performed single nucleus RNA sequencing in 24 Alzheimer's disease and …

Background Tumor glycolysis is a critical event for tumor progression. Docetaxel is widely
used as a first-line drug for chemotherapy and shown to have a survival advantage …

Signaling by TGF-β/Smad3 plays a key role in renal fibrosis. As obesity is one of the major
risk factors of chronic and end-stage renal disease, we studied the role of Smad3 signaling …

TGF-β1 is a major mediator of airway tissue remodelling during atopic asthma and affects
tight junctions (TJs) of airway epithelia. However, its impact on TJs of ciliated epithelia is …

Atherosclerosis is the primary cause of cardiovascular disease. The development of plaque
complications, such as calcification and neo-angiogenesis, strongly impacts plaque stability …