The biochemical properties of articular cartilage rely on the biochemical composition and
integrity of its extracellular matrix. This matrix consists mainly of a collagen network and the …

The phenotype of individual hematopoietic cells, like all other differentiated mammalian
cells, is determined by selective transcription of a subset of the genes encoded within the …

INTRODUCTION Microglia, as the resident myeloid cells of the central nervous system, play
an important role in life-long brain maintenance and in pathology. Microglia are derived from …

Pluripotent hematopoietic stem cells have been studied extensively, but the events that
occur during their differentiation remain largely uncharted. To develop a system that allows …

The major myeloid blood cell lineages are generated from hematopoietic stem cells by
differentiation through a series of increasingly committed progenitor cells. Precise …

The purification of primitive human hematopoietic stem cells has been impaired by the
absence of repopulation assays. By using a stringent two-step strategy involving depletion of …

We have tested the hypothesis that multipotential hemopoietic stem and progenitor cells
prime several different lineage-affiliated programs of gene activity prior to unilineage …

At postconfluence, cultured bovine pericytes isolated from retinal capillaries form three‐
dimensional nodule‐like structures that mineralize. Using a combination of Northern and …

A systems-level understanding of a small but essential population of cells in development or
adulthood (eg somatic stem cells) requires accurate quantitative monitoring of genome-wide …

We demonstrate here that" promiscuous" expression of myeloid or lymphoid genes
precedes lineage commitment in hematopoiesis. Prospectively purified single common …