Complications of portal hypertension, including ascites, gastrointestinal bleeding, hepatic
hydrothorax, and hepatic encephalopathy, are associated with significant morbidity and …

Transjugular intrahepatic portosystemic shunt (TIPS) is an established treatment tool in
decompensated liver cirrhosis that has been shown to prolong transplant-free survival …

Non-invasive tests are increasingly being used to improve the diagnosis and
prognostication of chronic liver diseases across aetiologies. Herein, we provide the latest …

Summary The EASL Clinical Practice Guidelines (CPGs) on the management of hepatic
encephalopathy (HE) present evidence-based answers to a set of relevant questions (where …

Kupffer cells (KCs) are localized in liver sinusoids but extend pseudopods to parenchymal
cells to maintain their identity and serve as the body's central bacterial filter. Liver cirrhosis …

Abstract Background and Aims Large spontaneous portosystemic shunt (SPSS) is
associated with increased risk of HE in patients undergoing transjugular intrahepatic …

Abstract Background and Aims Although NASH can lead to severe clinical consequences,
including cirrhosis and hepatocellular carcinoma, no effective treatment is currently …

Objective Liver stiffness measurement (LSM) is a tool used to screen for significant fibrosis
and portal hypertension. The aim of this retrospective multicentre study was to develop an …

Abstract Background & Aims Ammonia levels predicted hospitalisation in a recent landmark
study not accounting for portal hypertension and systemic inflammation severity. We …

Background Cirrhosis leads to portal hypertension and to the consequent formation of
spontaneous portosystemic shunts (SPSSs), leading to complications related to the …