Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …

An open-label, first-in-human phase 1/2 study is being conducted to evaluate the safety and
efficacy of pancreatic endoderm cells (PECs) implanted in non-immunoprotective …

For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

Incredible strides have been made since the discovery of insulin almost 100 years ago.
Insulin formulations have improved dramatically, glucose levels can be measured …

Type 1 diabetes mellitus is an auto-immune disease causing the T-cell mediated destruction
of insulin-producing β-cells, resulting in chronic hyperglycemia. Current treatments such as …

Pancreatic β-cells are specialized to properly regulate blood glucose. Maintenance of the
mature β-cell phenotype is critical for glucose metabolism, and β-cell failure results in …

Objectives Thyroid hormone (T3) and high glucose concentrations are critical components of
β-cell maturation and function. In the present study, we asked whether T3 and glucose …

It is widely accepted that thyroid hormones (THs), secreted from the thyroid, play important
roles in energy metabolism. It is also known that THs also alter the functioning of other …

Pancreatic endocrine cells expressing the ghrelin gene and producing the ghrelin hormone
were first identified in 2002. These cells, named ε cells, were recognized as the fifth type of …