Adequate aqueous solubility has been one of the desired properties while selecting drug
molecules and other bio-actives for product development. Often solubility of a drug …

Oral delivery of drugs with poor aqueous solubility and poor enzymatic and/or metabolic
stability is very challenging. However, the advent of nanotechnology has revolutionized the …

Background The oral route is the most popular route for the clinical administration of drugs to
treat various diseases. Before a drug is absorbed into the blood circulation, it must undergo …

A solid self-nanoemulsifying drug-delivery system (solid SNEDDS) has been explored to
improve the solubility and dissolution profile of glipizide. SNEDDS preconcentrate was …

Candesartan cilexetil is widely used in the management of hypertension and heart failure.
The drug delivery encounters obstacles of poor aqueous solubility, efflux by intestinal P …

Although it is acknowledged that the main impediment of orally administered therapeutic
agents is their extensive and changeable pre-systemic metabolism, low absorption and …

Objective Nintedanib (NDNB) is a triple receptor tyrosine kinase inhibitor with poor solubility
in neutral conditions and low bioavailability. A self-microemulsifying drug delivery system …

A drug is effective in their molecular form; thus solubility in the biological fluid is important.
Pharmaceutical researchers are continuously working on the improvement of solubility of …

Supersaturating formulations are widely used to improve the oral bioavailability of poorly
soluble drugs. However, supersaturated solutions are thermodynamically unstable and such …

The aim of this study was to develop oil in water nanoemulsion of nimodipine intended for
oral use. Nimodipine is a calcium channel blocker that has poor oral bioavailability (3-30%) …