Update from the 5th Edition of the World Health Organization classification of head and neck tumors: nasal cavity, paranasal sinuses and skull base

LDR Thompson, JA Bishop - Head and Neck Pathology, 2022 - Springer
Abstract The World Health Organization Classification of Head and Neck Tumours recently
published the 5th edition. There are new entities, emerging entities, and significant updates …

DEK:: AFF2 fusion carcinomas of head and neck

K Ruangritchankul, A Sandison - Advances in Anatomic Pathology, 2023 - journals.lww.com
Abstract A novel DEK:: AFF2 fusion carcinoma was recently described in 29 patients who
originally presented with non-viral–associated nonkeratinizing squamous cell carcinoma …

Comprehensive molecular profiling of sinonasal teratocarcinosarcoma highlights recurrent SMARCA4 inactivation and CTNNB1 mutations

LM Rooper, A Agaimy, J Gagan… - The American journal …, 2023 - journals.lww.com
Sinonasal teratocarcinosarcoma (TCS) is a rare tumor defined by intermixed neuroepithelial,
mesenchymal, and epithelial elements. While its etiology was historically ambiguous, we …

[HTML][HTML] Nuclear expression of AFF2 C-terminus is a sensitive and specific ancillary marker for DEK:: AFF2 carcinoma of the sinonasal tract

YJ Kuo, JS Lewis Jr, T Truong, YC Yeh, RD Chernock… - Modern Pathology, 2022 - Elsevier
DEK:: AFF2 carcinoma of the sinonasal tract is an emerging entity. The tumor is typically
characterized by papillary proliferation of non-keratinizing squamous epithelial cells with …

Recurrent EWSR1:: COLCA2 fusions define a novel sarcoma with spindle/round cell morphology and strong predilection for the sinonasal tract

A Agaimy, M Baněčková, J De Almeida… - The American Journal …, 2023 - journals.lww.com
The last 2 decades have attended a dynamic evolution in the nosology of poorly
differentiated sinonasal tract malignancies, with several new molecularly defined entities …

Detection of salivary gland and sinonasal fusions by a next‐generation sequencing based, ligation‐dependent, multiplex RT‐PCR assay

MD Lanic, R Guérin, M Wassef, P Durdilly… - …, 2023 - Wiley Online Library
Aims The discovery of tumour type‐specific gene fusion oncogenes in benign and malignant
salivary gland and sinonasal (SGSN) tumours has significantly increased our knowledge …

Towards a molecular classification of sinonasal carcinomas: clinical implications and opportunities

C Taverna, A Agaimy, A Franchi - Cancers, 2022 - mdpi.com
Simple Summary In recent years, there have been several molecular and
immunohistochemical additions to the pathologic diagnosis of sinonasal malignancies that …

Human Papillomavirus in Sinonasal Tract Tumors–Another Head and Neck “Hot Spot” for Prognostically Favorable Viral Disease

JS Lewis Jr - Surgical Pathology Clinics, 2024 - Elsevier
Human papillomavirus (HPV) has been identified as a driver of many different types of
dysplasias, papillomas, and invasive carcinomas across the body. The database of …

Molecular basis and rationale for the use of targeted agents and immunotherapy in sinonasal cancers

A Esposito, E Stucchi, M Baronchelli… - Journal of Clinical …, 2022 - mdpi.com
Despite the progress of surgery, radiotherapy, and neoadjuvant chemotherapy, the
prognosis for advanced sinonasal cancers (SNCs) remains poor. In the era of precision …

Involvement of the p53‐p16/RB pathway control mechanism in early‐stage carcinogenesis in head and neck squamous cell carcinoma

T Mori - Pathology International, 2022 - Wiley Online Library
Head and neck squamous cell carcinoma develops through a heterogeneous process
involving human papillomavirus infection, smoking, and alcohol consumption. A …