Estradiol, either from peripheral or central origin, activates multiple molecular
neuroprotective and neuroreparative responses that, being mediated by estrogen receptors …

Astrocyte-mediated inflammation is associated with degenerative pathologies such as
Alzheimer's and Parkinson's diseases and multiple sclerosis. The acute inflammation and …

Ischemia-reperfusion injury (I/R injury) is a common feature of ischemic stroke which occurs
when blood supply is restored after a period of ischemia. Although stroke is an important …

In the last years there has been a considerable advance in the knowledge on the regulation
of astrocytes by sex steroids under physiological and pathological conditions. By the …

Different functional states determine glioblastoma (GBM) heterogeneity. Brain cancer cells
coexist with the glial cells in a functional syncytium based on a continuous metabolic …

The use of the carbohydrate glucose as an energetic source is essential for an adequate
function of the human body. The complex regulation of this molecule involves the …

There are sexual differences in the onset, prevalence, and outcome of numerous
neurological diseases. Thus, in Alzheimer's disease, multiple sclerosis, and major …

Obesity is considered one of the greatest risk to human health and is associated with several
factors including genetic components, diet, and physical inactivity. Recently, the relationship …

High concentrations of palmitic acid in plasma increase both the inflammation associated
with obesity and the susceptibility to develop a neurodegenerative event. In the brain, the …

Astrocytes play an important role in physiological, metabolic, and structural functions, and
when impaired, they can be involved in various pathologies including Alzheimer, focal …