The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders
Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (A β),
hyperphosphorylated Tau or α-synuclein (α-syn), present either alone or in the form of mixed …
hyperphosphorylated Tau or α-synuclein (α-syn), present either alone or in the form of mixed …
Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad
K Reddy, BV Dieriks - Molecular Neurodegeneration, 2022 - Springer
The aberrant accumulation of α-Synuclein within oligodendrocytes is an enigmatic,
pathological feature specific to Multiple system atrophy (MSA). Since the characterization of …
pathological feature specific to Multiple system atrophy (MSA). Since the characterization of …
Aggregate-prone brain regions in Parkinson's disease are rich in unique N-terminus α-synuclein conformers with high proteolysis susceptibility
JA Wiseman, HC Murray, RLMF Faull… - npj Parkinson's …, 2024 - nature.com
In Parkinson's disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates
form a myriad of conformational and truncational variants. Most antibodies used to detect …
form a myriad of conformational and truncational variants. Most antibodies used to detect …
Myo1d promotes alpha-synuclein transfer from brain microvascular endothelial cells to pericytes through tunneling nanotubes
Q Duan, Q Zhang, K Nie, R Huang, J Yang, P He, Z Tie… - Iscience, 2023 - cell.com
Summary α-Synuclein preformed fibrils (α-syn PFF) in the blood can cross the blood–brain
barrier and invade the central nervous system. Our previous study proved that α-syn PFF …
barrier and invade the central nervous system. Our previous study proved that α-syn PFF …
Human pericytes degrade diverse α-synuclein aggregates
Parkinson's disease (PD) is a progressive, neurodegenerative disorder characterised by the
abnormal accumulation of α-synuclein (α-syn) aggregates. Central to disease progression is …
abnormal accumulation of α-synuclein (α-syn) aggregates. Central to disease progression is …
Blood–brain barrier alterations and their impact on Parkinson's disease pathogenesis and therapy
K Lau, R Kotzur, F Richter - Translational Neurodegeneration, 2024 - Springer
There is increasing evidence for blood–brain barrier (BBB) alterations in Parkinson's
disease (PD), the second most common neurodegenerative disorder with rapidly rising …
disease (PD), the second most common neurodegenerative disorder with rapidly rising …
Cultured brain pericytes adopt an immature phenotype and require endothelial cells for expression of canonical markers and ECM genes
F Oliveira, O Bondareva… - Frontiers in Cellular …, 2023 - frontiersin.org
Pericytes (PCs) are essential components of the blood brain barrier. Brain PCs are critical
for dynamically regulating blood flow, for maintaining vascular integrity and their …
for dynamically regulating blood flow, for maintaining vascular integrity and their …
Revealing the mechanisms of blood–brain barrier in chronic neurodegenerative disease: an opportunity for therapeutic intervention
S Yu, X Chen, T Yang, J Cheng, E Liu… - Reviews in the …, 2024 - degruyter.com
The brain microenvironment is tightly regulated, and the blood–brain barrier (BBB) plays a
pivotal role in maintaining the homeostasis of the central nervous system. It effectively …
pivotal role in maintaining the homeostasis of the central nervous system. It effectively …
Potential Biomarkers in Cerebrospinal Fluid and Plasma for Dementia
Q He, W Wang, Y Xiong, C Tao, L Ma… - Journal of Alzheimer's …, 2024 - content.iospress.com
Background: The identification of biomarkers for different dementias in plasma and
cerebrospinal fluid (CSF) has made substantial progress. However, they are observational …
cerebrospinal fluid (CSF) has made substantial progress. However, they are observational …
Wrapping up the role of pericytes in Parkinson's disease
TJ Stevenson, BV Dieriks - Neural Regeneration Research, 2023 - journals.lww.com
Pericytes are classically defined as contractile cells within the central nervous system that
regulate blood flow and permeability of the blood-brain barrier (BBB). This one-sided view is …
regulate blood flow and permeability of the blood-brain barrier (BBB). This one-sided view is …