Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (A β),
hyperphosphorylated Tau or α-synuclein (α-syn), present either alone or in the form of mixed …

The aberrant accumulation of α-Synuclein within oligodendrocytes is an enigmatic,
pathological feature specific to Multiple system atrophy (MSA). Since the characterization of …

In Parkinson's disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates
form a myriad of conformational and truncational variants. Most antibodies used to detect …

Summary α-Synuclein preformed fibrils (α-syn PFF) in the blood can cross the blood–brain
barrier and invade the central nervous system. Our previous study proved that α-syn PFF …

Parkinson's disease (PD) is a progressive, neurodegenerative disorder characterised by the
abnormal accumulation of α-synuclein (α-syn) aggregates. Central to disease progression is …

There is increasing evidence for blood–brain barrier (BBB) alterations in Parkinson's
disease (PD), the second most common neurodegenerative disorder with rapidly rising …

Pericytes (PCs) are essential components of the blood brain barrier. Brain PCs are critical
for dynamically regulating blood flow, for maintaining vascular integrity and their …

The brain microenvironment is tightly regulated, and the blood–brain barrier (BBB) plays a
pivotal role in maintaining the homeostasis of the central nervous system. It effectively …

Background: The identification of biomarkers for different dementias in plasma and
cerebrospinal fluid (CSF) has made substantial progress. However, they are observational …

Pericytes are classically defined as contractile cells within the central nervous system that
regulate blood flow and permeability of the blood-brain barrier (BBB). This one-sided view is …