The blood–brain barrier, which is formed by tightly interconnected microvascular endothelial
cells, separates the brain from the peripheral circulation. Together with other central nervous …

Glioblastoma (GBM) is an aggressive malignancy of the central nervous system (CNS) that
remains incurable despite the multitude of improvements in cancer therapeutics. The …

Background Approximately 20% of all cancer patients will develop brain metastases in their
lifespan. The standard of care for patients with multiple brain metastases is whole-brain …

Patients with metastatic breast cancer have high and continually increasing rates of brain
metastases. During the course of the disease, brain metastases can occur in up to 30% of …

Cancer metastases into the brain constitute one of the most severe, but not uncommon,
manifestations of cancer progression. Several factors control how cancer cells interact with …

Older people represent the fastest growing group with epilepsy diagnosis. For example,
cerebrovascular disease may underlie roughly 30–50% of epilepsy in older adults and …

Neurodegenerative disorders (NDs) are expected to pose a significant challenge for both
medicine and public health in the upcoming years due to global demographic changes. NDs …

Intratumoral injection of anticancer agents has limited efficacy and is not routinely used for
most cancers. In this study, we aimed to improve the efficacy of intratumoral chemotherapy …

The efforts to use novel nanotechnologies in medicine and cancer have been widespread.
In order to understand better the focus areas of cancer nanomedicine research to date, we …

Purpose To investigate ferumoxytol (FMX)-enhanced MRI as a pretreatment predictor of
response to liposomal irinotecan (nal-IRI) for thoracoabdominal and brain metastases in …