Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium
MCS Lee, SE Lindner, JJ Lopez-Rubio… - Briefings in functional …, 2019 - academic.oup.com
CRISPR/Cas9 approaches are revolutionizing our ability to perform functional genomics
across a wide range of organisms, including the Plasmodium parasites that cause malaria …
across a wide range of organisms, including the Plasmodium parasites that cause malaria …
Malaria parasite translocon structure and mechanism of effector export
The putative Plasmodium translocon of exported proteins (PTEX) is essential for transport of
malarial effector proteins across a parasite-encasing vacuolar membrane into host …
malarial effector proteins across a parasite-encasing vacuolar membrane into host …
Label-free target protein characterization for small molecule drugs: recent advances in methods and applications
F Feng, W Zhang, Y Chai, D Guo, X Chen - Journal of Pharmaceutical and …, 2023 - Elsevier
Target protein identification is the key to identification of the mechanisms, side effects, and
evaluating druglikeness of small-molecule drugs. The commonly used “labeled” target …
evaluating druglikeness of small-molecule drugs. The commonly used “labeled” target …
Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion
Proteases of the malaria parasite Plasmodium falciparum have long been investigated as
drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins …
drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins …
A PPP-type pseudophosphatase is required for the maintenance of basal complex integrity in Plasmodium falciparum
AA Morano, RM Rudlaff, JD Dvorin - Nature Communications, 2023 - nature.com
During its asexual blood stage, P. falciparum replicates via schizogony, wherein dozens of
daughter cells are formed within a single parent. The basal complex, a contractile ring that …
daughter cells are formed within a single parent. The basal complex, a contractile ring that …
EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX
Intraerythrocytic malaria parasites reside within a parasitophorous vacuolar membrane
(PVM) generated during host cell invasion. Erythrocyte remodelling and parasite metabolism …
(PVM) generated during host cell invasion. Erythrocyte remodelling and parasite metabolism …
An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes
The malaria parasite, Plasmodium falciparum, displays the P. falciparum erythrocyte
membrane protein 1 (Pf EMP1) on the surface of infected red blood cells (RBCs). We here …
membrane protein 1 (Pf EMP1) on the surface of infected red blood cells (RBCs). We here …
Critical role for isoprenoids in apicoplast biogenesis by malaria parasites
M Okada, K Rajaram, RP Swift, A Mixon, JA Maschek… - Elife, 2022 - elifesciences.org
Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle
in Plasmodium falciparum malaria parasites and is required for prenylation-dependent …
in Plasmodium falciparum malaria parasites and is required for prenylation-dependent …
Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis
Plasmodium parasites possess a protein with homology to Niemann-Pick Type C1 proteins
(Niemann-Pick Type C1-Related protein, NCR1). We isolated parasites with resistance …
(Niemann-Pick Type C1-Related protein, NCR1). We isolated parasites with resistance …
Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer's clefts vesiculation, host cell remodeling defects, and loss of surface presentation of …
Presentation of the variant antigen, Plasmodium falciparum erythrocyte membrane protein 1
(EMP1), at knob-like protrusions on the surface of infected red blood cells, underpins the …
(EMP1), at knob-like protrusions on the surface of infected red blood cells, underpins the …