Alzheimer's disease: a review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment
P dos Santos, C Leide, PF Ozela… - Current medicinal …, 2018 - ingentaconnect.com
Dementia is characterized by the impairment of cognition and behavior of people over 65
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …
A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease
P Anand, B Singh, N Singh - Bioorganic & medicinal chemistry, 2012 - Elsevier
Acetylcholinesterase (AChE) enzyme inhibition is an important target for the management of
Alzheimer disease (AD) and AChE inhibitors are the main stay drugs for its management …
Alzheimer disease (AD) and AChE inhibitors are the main stay drugs for its management …
Acetylcholinesterase inhibitors: pharmacology and toxicology
MB Colovic, DZ Krstic… - Current …, 2013 - ingentaconnect.com
Acetylcholinesterase is involved in the termination of impulse transmission by rapid
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …
Structures of human acetylcholinesterase in complex with pharmacologically important ligands
J Cheung, MJ Rudolph, F Burshteyn… - Journal of medicinal …, 2012 - ACS Publications
Human acetylcholinesterase (AChE) is a significant target for therapeutic drugs. Here we
present high resolution crystal structures of human AChE, alone and in complexes with drug …
present high resolution crystal structures of human AChE, alone and in complexes with drug …
Assessment of enzyme inhibition: a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs
RR Ramsay, KF Tipton - Molecules, 2017 - mdpi.com
The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …
Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease and type 2 diabetes mellitus
Both Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2DM) share the presence of
systemic and neuro-inflammation, enhanced production and accumulation of β-amyloid …
systemic and neuro-inflammation, enhanced production and accumulation of β-amyloid …
[PDF][PDF] Cholinesterases, a target of pharmacology and toxicology.
M Pohanka - Biomedical Papers of the Medical Faculty of …, 2011 - pdfs.semanticscholar.org
Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter
acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and …
acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and …
Acetylcholinesterase:'classical'and 'non-classical'functions and pharmacology
I Silman, JL Sussman - Current opinion in pharmacology, 2005 - Elsevier
The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic
synapses by rapidly hydrolysing acetylcholine. It is anchored within the synaptic cleft by a …
synapses by rapidly hydrolysing acetylcholine. It is anchored within the synaptic cleft by a …
Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease
EL Konrath, CS Passos, LC Klein-Júnior… - Journal of Pharmacy …, 2013 - academic.oup.com
Objectives The inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown
of acetylcholine, is currently the main pharmacological strategy available for Alzheimer's …
of acetylcholine, is currently the main pharmacological strategy available for Alzheimer's …
3-(4-{[Benzyl(methyl)amino]methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) Inhibits Both Acetylcholinesterase and Acetylcholinesterase-Induced β …
L Piazzi, A Rampa, A Bisi, S Gobbi… - Journal of medicinal …, 2003 - ACS Publications
In recent years, the investigation of acetylcholinesterase (AChE) inhibitors has gained
further interest, because the involvement of the peripheral site of the enzyme in the β …
further interest, because the involvement of the peripheral site of the enzyme in the β …