Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in
the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from …

Iron-chelation therapy has its origins in the treatment of iron-overload syndromes. For many
years, the standard for this purpose has been deferoxamine. Recently, considerable …

Cardiac and endocrine disorders are common sequelae of iron overload in transfused
thalassaemia patients. Combined chelation with desferrioxamine (DFO) and deferiprone …

Thalassemia syndromes are characterized by the inability to produce normal hemoglobin.
Ineffective erythropoiesis and red cell transfusions are sources of excess iron that the human …

The life of patients with thalassemia has improved both in duration and in quality in
industrialized countries. Complications are still common and include heart disease (heart …

Zinc (Zn), copper (Cu) and iron (Fe) are essential minerals that are required for a variety of
biomolecules to maintain the normal structure, function, and proliferation of cells. These …

Diabetes of the exocrine pancreas (DEP) is a form of diabetes that occurs due to pancreatic
disease. It is far more common than has been previously considered, with a recent study …

Pancreatic iron overload and diabetes mellitus (DM) are common in thalassemia major
patients. However, the relationship between iron stores and glucose disturbances is not well …

OBJECTIVE We systematically explored the link of pancreatic iron with glucose metabolism
and with cardiac complications in a cohort of 1,079 patients with thalassemia major (TM) …

Iron is one of the essential minerals that are required for a variety of molecules to maintain
their normal structures and functions and for cells to live, grow, and proliferate. The …