Ankylosing spondylitis risk factors: a systematic literature review
MC Hwang, L Ridley, JD Reveille - Clinical rheumatology, 2021 - Springer
Radiographic axial spondyloarthritis (also known as ankylosing spondylitis [AS]) is a chronic
immune-mediated arthritis characterized by inflammation of the axial skeleton, peripheral …
immune-mediated arthritis characterized by inflammation of the axial skeleton, peripheral …
The pathogenesis of ankylosing spondylitis: an update
SJ Pedersen, WP Maksymowych - Current rheumatology reports, 2019 - Springer
Abstract Purpose of Review Ankylosing spondyloarthritis (AS) is a chronic inflammatory
disease that involves the axial joints and entheses. Extra-spinal manifestations such as …
disease that involves the axial joints and entheses. Extra-spinal manifestations such as …
Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity
Y Zhai, L Chen, Q Zhao, ZH Zheng, ZN Chen, H Bian… - Science, 2023 - science.org
Autoimmune diseases such as ankylosing spondylitis (AS) can be driven by emerging
neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile …
neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile …
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
JM Hildebrand, M Kauppi, IJ Majewski, Z Liu… - Nature …, 2020 - nature.com
MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have
isolated a mouse strain with a single missense mutation, Mlkl D139V, that alters the two …
isolated a mouse strain with a single missense mutation, Mlkl D139V, that alters the two …
HLA-B* 27 and ankylosing spondylitis: 50 years of insights and discoveries
MA Khan - Current Rheumatology Reports, 2023 - Springer
Abstract Purpose of Review To commemorate the 50th anniversary of the groundbreaking
discovery of a remarkably strong association between HLA-B* 27 and ankylosing spondylitis …
discovery of a remarkably strong association between HLA-B* 27 and ankylosing spondylitis …
B cell involvement in the pathogenesis of ankylosing spondylitis
R Wilbrink, A Spoorenberg, GMPJ Verstappen… - International journal of …, 2021 - mdpi.com
Extensive research into ankylosing spondylitis (AS) has suggested the major role of
genetics, immune reactions, and the joint–gut axis in its etiology, although an ultimate …
genetics, immune reactions, and the joint–gut axis in its etiology, although an ultimate …
HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications
R Busch, S Kollnberger, ED Mellins - Nature Reviews Rheumatology, 2019 - nature.com
Our understanding of the mechanisms underlying HLA associations with inflammatory
arthritis continues to evolve. Disease associations have been refined, and interactions of …
arthritis continues to evolve. Disease associations have been refined, and interactions of …
[HTML][HTML] Genomewide association study of acute anterior uveitis identifies new susceptibility loci
Purpose: Acute anterior uveitis (AAU) is a common intraocular inflammatory disease. AAU
occurs in 30% to 50% of patients with ankylosing spondylitis (AS), and both conditions are …
occurs in 30% to 50% of patients with ankylosing spondylitis (AS), and both conditions are …
Genetics and the axial spondyloarthritis spectrum
The axial SpAs (axSpAs) are clearly clinically a heterogeneous set of diseases with
markedly varying extra-articular features. These diseases are all highly heritable and have …
markedly varying extra-articular features. These diseases are all highly heritable and have …