Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their
function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription …

Matrix metalloproteinases (MMPs) and proteins containing a disintegrin and
metalloproteinase domain (ADAM) are important in neuroinflammation, and recent studies …

Uncontrolled proliferation and abnormal cell migration are two of the main characteristics of
tumour growth. Of ultimate importance is the question what are the mechanisms that trigger …

Glioblastoma (GBM) is the most common and malignant primary brain cancer in adults.
Without treatment the mean patient survival is approximately 6 months, which can be …

Hypoxia is a common feature of many solid tumors, including hepatocellular carcinoma
(HCC). Hypoxia can promote tumor progression and induce radiation and chemotherapy …

Cancer cells evolve in the tumor microenvironment (TME) by the acquisition of
characteristics that allow them to initiate their passage through a series of events that …

Liver disease is a growing global health problem, as deaths from end-stage liver cirrhosis
and cancer are rising across the world. At present, pharmacologic approaches to effectively …

Malignant brain tumors are devastating despite aggressive treatments such as surgical
resection, chemotherapy and radiation therapy. The average life expectancy of patients with …