[HTML][HTML] Omicron variant (B. 1.1. 529) of SARS-CoV-2: Mutation, infectivity, transmission, and vaccine resistance

SY Ren, WB Wang, RD Gao… - World journal of clinical …, 2022 - ncbi.nlm.nih.gov
The appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant
Omicron (B. 1.1. 529) has caused panic responses around the world because of its high …

[PDF][PDF] Adaptive immunity to SARS-CoV-2 and COVID-19

A Sette, S Crotty - Cell, 2021 - cell.com
The adaptive immune system is important for control of most viral infections. The three
fundamental components of the adaptive immune system are B cells (the source of …

[HTML][HTML] Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron

JM Carreño, H Alshammary, J Tcheou, G Singh… - Nature, 2022 - nature.com
Abstract The Omicron (B. 1.1. 529) variant of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) was initially identified in November 2021 in South Africa and Botswana, as …

[PDF][PDF] Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

S Afkhami, MR D'Agostino, A Zhang, HD Stacey… - Cell, 2022 - cell.com
The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current
COVID-19 vaccines administered intramuscularly and designed to only target the spike …

[HTML][HTML] Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost

F Muecksch, Z Wang, A Cho, C Gaebler, T Ben Tanfous… - Nature, 2022 - nature.com
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent
individuals,–. Despite the reduced protection from infection, individuals who received three …

Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses

T Mao, B Israelow, MA Peña-Hernández, A Suberi… - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
highlighted the need for vaccines that not only prevent disease but also prevent …

[PDF][PDF] Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

MG Alameh, I Tombácz, E Bettini, K Lederer… - Immunity, 2021 - cell.com
Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …

[HTML][HTML] Long COVID in a prospective cohort of home-isolated patients

B Blomberg, KGI Mohn, KA Brokstad, F Zhou… - Nature medicine, 2021 - nature.com
Long-term complications after coronavirus disease 2019 (COVID-19) are common in
hospitalized patients, but the spectrum of symptoms in milder cases needs further …

[HTML][HTML] SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

J Zahradník, S Marciano, M Shemesh, E Zoler… - Nature …, 2021 - nature.com
SARS-CoV-2 variants of interest and concern will continue to emerge for the duration of the
COVID-19 pandemic. To map mutations in the receptor-binding domain (RBD) of the spike …

[HTML][HTML] Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection

Z Wang, F Muecksch, D Schaefer-Babajew, S Finkin… - Nature, 2021 - nature.com
More than one year after its inception, the coronavirus disease 2019 (COVID-19) pandemic
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains difficult …