▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

The strength and integrity of our bones depends on maintaining a delicate balance between
bone resorption by osteoclasts and bone formation by osteoblasts. As we age or as a result …

Considerable evidence now implicates elevated expression and/or activity of Src in cancer
development. In cells, endogenous Src is switched from an inactive to an active state by a …

Osteosarcoma is the most common primary malignancy of bone. It arises in bone during
periods of rapid growth and primarily affects adolescents and young adults. The 5‐year …

Once osteoblasts have completed their bone‐forming function, they are either entrapped in
bone matrix and become osteocytes or remain on the surface as lining cells. Nonetheless …

Ligand-induced down-regulation of two growth factor receptors, EGF receptor (ErbB-1) and
ErbB-3, correlates with differential ability to recruit c-Cbl, whose invertebrate orthologs are …

The osteoclast is a hematopoietic cell derived from CFU-GM and branches from the
monocyte-macrophage lineage early during the differentiation process. The marrow …

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein
tyrosine kinases which, when activated, initiate the formation of protein complexes that …

Segregation of TRAF6‐mediated signaling pathways clarifies its role in osteoclastogenesis |
The EMBO Journal All EMBO Press journals Open Access as of 1 January 2024 - read the …

TRANCE, a TNF family member, and its receptor, TRANCE-R, are critical regulators of
dendritic cell and osteoclast function. Here, we demonstrate that TRANCE activates the …