As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal
proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The …

The eukaryotic 26S proteasome is a large multisubunit complex that degrades the majority
of proteins in the cell under normal conditions. The 26S proteasome can be divided into two …

The proteasome is an ATP-dependent, 2.5-megadalton molecular machine that is
responsible for selective protein degradation in eukaryotic cells. Here we present cryo …

The eukaryotic ubiquitin-proteasome system is responsible for most aspects of regulatory
and quality-control protein degradation in cells. Its substrates, which are usually modified by …

The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that
controls chromosome segregation and mitotic exit. Its regulation by coactivator subunits …

Protein degradation in eukaryotic cells is performed by the Ubiquitin-Proteasome System
(UPS). The 26S proteasome holocomplex consists of a core particle (CP) that proteolytically …

INTRODUCTION The ubiquitin-proteasome system comprises hundreds of distinct pathways
of degradation, which converge at the step of ubiquitin recognition by the proteasome. Five …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3
ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of …

The 26S proteasome operates at the executive end of the ubiquitin-proteasome pathway.
Here, we present a cryo-EM structure of the Saccharomyces cerevisiae 26S proteasome at a …