A growing body of research, especially in recent years, has shown that bacterial
extracellular vesicles (bEVs) are one of the key underlying mechanisms behind the …

End-stage organ failure is a key challenge for the medical community because of the ageing
population and the severe shortage of suitable donor organs available. Equally, injuries to …

Prophylactic vaccines for SARS-CoV-2 have lowered the incidence of severe COVID-19, but
emergence of viral variants that are antigenically distinct from the vaccine strains are of …

Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including
secreted bacterial products. Here, using human primary sinonasal air-liquid interface …

The respiratory tract is exceptionally well defended against infection from inhaled bacteria,
with multiple proinflammatory signaling cascades recruiting phagocytes to clear airway …

EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

Recellularization of whole decellularized lung scaffolds provides a novel approach for
generating functional lung tissue ex vivo for subsequent clinical transplantation. To explore …

Taste receptors were first identified on the tongue, where they initiate a signaling pathway
that communicates information to the brain about the nutrient content or potential toxicity of …

Abstract Objectives/Hypothesis: Although the pathophysiology leading to rhinosinusitis is
complex, evidence indicates that decreased mucociliary clearance (MCC) is a major …

The activation of type I IFN signaling is a major component of host defense against viral
infection, but it is not typically associated with immune responses to extracellular bacterial …