Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …

Pioneer transcription factors have the ability to access DNA in compacted chromatin.
Multiple transcription factors can bind together to a regulatory element in a cooperative way …

Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Introduction: Regenerative medicine involves research in a number of fields and disciplines
such as stem cell research, tissue engineering and biological therapy in general. As …

Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct
conversions between differentiated cell lineages represent powerful approaches to engineer …

Stem cells are a population of undifferentiated cells characterized by the ability to
extensively proliferate (self-renewal), usually arise from a single cell (clonal), and …

Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells
to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through …

The molecular and physical information coded within the extracellular milieu is informing the
development of a new generation of biomaterials for tissue engineering. Several powerful …