The role of immune activation in psychiatric disorders has attracted considerable attention
over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the …

A major challenge in Parkinson's disease is the variability in symptoms and rates of
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …

The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly
understood, and reported disease effects on the brain vary widely between studies. In an …

This work describes a new diffusion MR framework for imaging and modeling of
microstructure that we call q-space trajectory imaging (QTI). The QTI framework consists of …

Background Neuroinflammation and white matter pathology have each been independently
associated with schizophrenia, and experimental studies have revealed mechanisms by …

The high societal and individual cost of schizophrenia necessitates finding better, more
effective treatment, diagnosis, and prevention strategies. One of the obstacles in this …

In patients with schizophrenia neuroimaging studies have revealed global differences with
some brain regions showing focal abnormalities. Examining neurocircuitry, diffusion …

It is evident that once psychosis is present in patients with schizophrenia, the underlying
biological process of the illness has already been ongoing for many years. At the time of …

Background Perineuronal nets (PNNs) are extracellular matrix structures that enwrap many
neurons in the brain. They regulate the postnatal experience-dependent maturation of brain …

Schizophrenia is a psychotic disorder characterized by delusions, hallucinations, negative
symptoms, as well as behavioral and cognitive dysfunction. It is a pathoetiologically …