The development of monoclonal antibody treatments for successful tumor-targeted therapies
took several decades. However, the efficacy of antibody-based therapy is still confined and …

The second messenger cyclic adenosine monophosphate (cAMP) can bind and activate
protein kinase A (PKA). The cAMP/PKA system is ubiquitous and involved in a wide array of …

Tremendous effort has been expended over the past two and a half decades to understand
many aspects of camelid heavy chain antibodies, from their biology, evolution, and …

Introduction The pleiotropic cytokine interleukin-6 (IL-6) plays an important role in the
pathogenesis of different diseases, including rheumatoid arthritis (RA). ALX-0061 is a …

Chimeric antigen receptor (CAR) immunotherapy has recently shown promise in clinical
trials for B-cell malignancies; however, designing CARs for T-cell based diseases remain a …

Detection of intracerebral targets with imaging probes is challenging due to the non-
permissive nature of blood-brain barrier (BBB). The present work describes two novel single …

CD38, as a cell surface antigen is highly expressed in several hematologic malignancies
including multiple myeloma (MM) and has been proven to be a good target for …

Abstract South American Camelids (SACs) make several material and non-material
contributions to people and are a key component of the Andean biocultural heritage. From …

Omicron, a variant of concern (VOC) of SARS-CoV-2, emerged in South Africa in November
2021. Omicron has been continuously acquiring a series of new mutations, especially in the …

Targeted delivery of therapeutics is an alternative approach for the selective treatment of
infectious diseases. The surface of African trypanosomes, the causative agents of African …