Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

Background Epithelial and endothelial barrier integrity, essential for homeostasis, is
maintained by cellular boarder structures known as tight junctions (TJs). In critical illness …

Disrupted development of the gut microbiota is a contributing cause of childhood
malnutrition. Bifidobacterium longum subspecies infantis is a prominent early colonizer of …

Background The intestine of children with severe malnutrition (SM) shows structural and
functional changes that are linked to increased infection and mortality. SM dysregulates the …

Acute malnutrition, or wasting, is implicated in over half of all deaths in children under five
and increases risk of infectious disease. Studies in humans and preclinical models have …

Environmental enteropathy is a major contributor to growth faltering in millions of children in
Africa and South Asia. We carried out a longitudinal, observational and interventional study …

The gastrointestinal (GI) epithelium plays a major role in nutrient absorption, barrier
formation, and innate immunity. The development of organoid-based methodology has …

High mortality after discharge from hospital following acute illness has been observed
among children with Severe Acute Malnutrition (SAM). However, mechanisms that may be …

Severe acute malnutrition (SAM) is the most high-risk form of undernutrition, particularly
when children require hospitalization for complications. Complicated SAM is a multisystem …

Malnutrition underlies almost half of all child deaths globally. Severe Acute Malnutrition
(SAM) carries unacceptable mortality, particularly if accompanied by infection or medical …