Electrolyte transport in the mammalian colon: mechanisms and implications for disease

K Kunzelmann, M Mall - Physiological reviews, 2002 - journals.physiology.org
The colonic epithelium has both absorptive and secretory functions. The transport is
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …

Role of colonic short-chain fatty acid transport in diarrhea

HJ Binder - Annual review of physiology, 2010 - annualreviews.org
Short-chain fatty acids (SCFA) are the major anion in stool and are synthesized from
nonabsorbed carbohydrate by the colonic microbiota. Nonabsorbed carbohydrate are not …

MOLECULAR PHYSIOLOGY OF INTESTINAL N+/H+ EXCHANGE

NC Zachos, M Tse, M Donowitz - Annu. Rev. Physiol., 2005 - annualreviews.org
▪ Abstract The sodium/hydrogen exchange (NHE) gene family plays an integral role in
neutral sodium absorption in the mammalian intestine. The NHE gene family is comprised of …

Traditional and emerging roles for the SLC9 Na+/H+ exchangers

DG Fuster, RT Alexander - Pflügers Archiv-European Journal of Physiology, 2014 - Springer
The SLC9 gene family encodes Na+/H+ exchangers (NHEs). These transmembrane
proteins transport ions across lipid bilayers in a diverse array of species from prokaryotes to …

Regulatory binding partners and complexes of NHE3

M Donowitz, X Li - Physiological reviews, 2007 - journals.physiology.org
NHE3 is the brush-border (BB) Na+/H+ exchanger of small intestine, colon, and renal
proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a …

Glucocorticoid activation of Na+/H+ exchanger isoform 3 revisited: the roles of SGK1 and NHERF2

CC Yun, Y Chen, F Lang - Journal of Biological Chemistry, 2002 - ASBMB
The stimulative effect of glucocorticoids on intestinal salt and water absorption has been
known for more than two decades. However, molecular mechanisms underlying this …

Secretion and absorption by colonic crypts

JP Geibel - Annu. Rev. Physiol., 2005 - annualreviews.org
▪ Abstract The intestines play an important role in the absorption and secretion of nutrients.
The colon is the final area for recapturing electrolytes and water prior to excretion, and in …

[HTML][HTML] SLC9 gene family: function, expression, and regulation

H Xu, FK Ghishan, PR Kiela - Comprehensive Physiology, 2018 - ncbi.nlm.nih.gov
Abstract The Slc9 family of Na+/H+ exchangers (NHEs) plays a critical role in electroneutral
exchange of Na+ and H+ in the mammalian intestine as well as other absorptive and …

Mechanisms of the Regulation of the Intestinal Na+/H+Exchanger NHE3

P He, CC Yun - BioMed Research International, 2010 - Wiley Online Library
A major of Na+ absorptive process in the proximal part of intestine and kidney is
electroneutral exchange of Na+ and H+ by Na+/H+ exchanger type 3 (NHE3). During the …

[HTML][HTML] Colonic potassium absorption and secretion in health and disease

VM Rajendran, GI Sandle - Comprehensive Physiology, 2018 - ncbi.nlm.nih.gov
The colon has large capacities for K+ absorption and K+ secretion, but its role in maintaining
K+ homeostasis is often overlooked. For many years, passive diffusion and/or solvent drag …