Pancreatic islet beta cells are essential for maintaining glucose homeostasis. To understand
the impact of aging on beta cells, we performed meta-analysis of single-cell RNA …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

Abstract Objective Pancreatic islets of Langerhans secrete hormones to regulate systemic
glucose levels. Emerging evidence suggests that islet cells are functionally heterogeneous …

Human islet primary cilia are vital glucose-regulating organelles whose structure remains
uncharacterized. Scanning electron microscopy (SEM) is a useful technique for studying the …

Pancreatic β-cells are specialized to properly regulate blood glucose. Maintenance of the
mature β-cell phenotype is critical for glucose metabolism, and β-cell failure results in …

I review recent technological advancements in coupling single-cell transcriptomics with
cellular phenotypes including morphology, calcium signaling, and electrophysiology. Single …

β-cells are insulin-producing cells in the pancreas that maintain euglycemic conditions.
Pancreatic β-cell maturity and function are regulated by a variety of transcription factors that …

In commemoration of 100 years since the discovery of glucagon, we review current
knowledge about the human α cell. Alpha cells make up 30–40% of human islet endocrine …