Background: A growing body of evidence has shed light on the role of the hemostatic
pathway and its components in the pathogenesis of multiple sclerosis (MS), particularly in …

Methylenetetrahydrofolate reductase (MTHFR) is a critical rate‐limiting enzyme in the
homocysteine/methionine metabolism pathway that is implicated in the pathogenesis and …

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in breast
cancer: a Sardinian preliminary case-control study - PMC Back to Top Skip to main content NIH …

Background Multiple studies have evaluated the associations between 5, 10‐
methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and …

Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system. The
inflammatory and neurodegenerative pathways driving MS are modulated by DNA, lysine …

Objectives To identify genes that confer MS risk via the alteration of cis‐regulated protein
abundance and verify their aberrant expression in human brain. Methods Utilizing a two …

Aim: To investigate the relationships of polymorphisms in genes whose protein products are
related in the metabolic pathway of folic acid, particularly MTRR A66G, RFC1 G80A, and …

Multiple sclerosis (MS) is a degenerative disease of the central nervous system in which
auto-immunity-induced demyelination occurs. MS is thought to be caused by a complex …

Background Interactions between genetic and environmental variables contribute to the
autoimmune inflammatory process in multiple sclerosis (MS). Elevated homocysteine levels …

Background: The methylene tetrahydrofolate reductase (MTHFR) is a folate-dependent
enzyme which catalyzes the conversion of homocysteine to methionine. Two single …