KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
E Crisman, P Duarte, E Dauden… - Medicinal research …, 2023 - Wiley Online Library
The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the
master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective …
master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective …
The Keap1–Nrf2–ARE pathway as a potential preventive and therapeutic target: an update
MC Lu, JA Ji, ZY Jiang, QD You - Medicinal research reviews, 2016 - Wiley Online Library
Abstract The Keap1–Nrf2–ARE ((Kelch‐like ECH‐Associating protein 1) nuclear factor
erythroid 2 related factor 2‐antioxidant response element) pathway is one of the most …
erythroid 2 related factor 2‐antioxidant response element) pathway is one of the most …
[HTML][HTML] Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
AT Dinkova-Kostova, RV Kostov, P Canning - Archives of biochemistry and …, 2017 - Elsevier
The Kelch-like ECH associated protein 1 (Keap1) is a component of a Cullin3-based Cullin-
RING E3 ubiquitin ligase (CRL) multisubunit protein complex. Within the CRL, homodimeric …
RING E3 ubiquitin ligase (CRL) multisubunit protein complex. Within the CRL, homodimeric …
[HTML][HTML] The KEAP1-NRF2 system in healthy aging and longevity
D Matsumaru, H Motohashi - Antioxidants, 2021 - mdpi.com
Aging is inevitable, but the inherently and genetically programmed aging process is
markedly influenced by environmental factors. All organisms are constantly exposed to …
markedly influenced by environmental factors. All organisms are constantly exposed to …
[HTML][HTML] Potential applications of NRF2 modulators in cancer therapy
The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …
Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis
Y Zhang, T Yan, D Sun, C Xie, T Wang, X Liu… - Free Radical Biology …, 2020 - Elsevier
Inflammatory bowel disease (IBD) represents a group of chronic relapsing intestinal
disorders. Rutaecarpine (RUT), isolated from the Traditional Chinese Medicine (TCM) of …
disorders. Rutaecarpine (RUT), isolated from the Traditional Chinese Medicine (TCM) of …
The role of natural products in revealing NRF2 function
Covering: up to 2020 The transcription factor NRF2 is one of the body's major defense
mechanisms, driving transcription of> 300 antioxidant response element (ARE)-regulated …
mechanisms, driving transcription of> 300 antioxidant response element (ARE)-regulated …
Targeting NRF2 to treat cancer
NRF2 is a basic leucine zipper (bZip) transcription factor that is the master regulator of redox
homeostasis. Under basal conditions, the cellular level of NRF2 is low due to a …
homeostasis. Under basal conditions, the cellular level of NRF2 is low due to a …
A multimodal deep learning framework for predicting PPI-modulator interactions
Protein–protein interactions (PPIs) are essential for various biological processes and
diseases. However, most existing computational methods for identifying PPI modulators …
diseases. However, most existing computational methods for identifying PPI modulators …
Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
S Lee, L Hu - Medicinal Chemistry Research, 2020 - Springer
Activation of the transcription factor Nrf2 via the Keap1–Nrf2–ARE signaling system
regulates the transcription and subsequent expression of cellular cytoprotective proteins and …
regulates the transcription and subsequent expression of cellular cytoprotective proteins and …