A critically important process in catalysis is the formation of an active catalyst from the
combination of a metal precursor and a ligand, as the efficacy of this reaction governs the …

Identification of potent anticancer agents with high selectivity and low toxicity remains on the
way to human health. Pyridazine featuring advantageous physicochemical properties and …

Pharmacologic inhibition of the oncogenic protein kinases using small molecules is a
promising strategy to combat several human malignancies. CDK1 is an example of such a …

Fused diaza-heterocycles constitute the core structure of numerous bioactive natural
products and effective therapeutic drugs. Among them, phthalazines have been recognized …

Achieving high molecular complexity can be not trivial, but the exploitation of domino
reactions provides an atom‐and step‐economical method to reach this target. Over the past …

Phthalazine derivatives have recently received a lot of interest in the realm of physiologically
active chemical research. Introduce this phthalazine moiety to a researcher in a new …

Sulfonamide compounds, also known as sulfa drugs, are a significant class of synthetic
bacteriostatic antimicrobials and were the primary source of therapy against bacterial …

A robust design and synthesis of novel phthalazinone based indole-pyran hybrids as
cytotoxic agents is described. A relatively safer ionic liquid medium ([BMIM] BF 4) was …

Microwave (MW) assisted reactions have became a powerful tool in azaheterocycles
chemistry during the last decades. Five and six membered ring azaheterocycles are …

We report a novel approach for surface-enhanced Raman spectroscopy (SERS) detection in
digital microfluidics (DMF). This is made possible by a microspray hole (μSH) that uses an …