Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein
B–containing lipoproteins. Local biological responses to these retained lipoproteins …

Recent advances in human genetics, together with a large body of epidemiologic,
preclinical, and clinical trial results, provide strong support for a causal association between …

The purpose of this article is to review the basic and clinical science relating plasma
triglycerides and cardiovascular disease. Although many aspects of the basic physiology of …

The ABC transporter ABCA1 plays a key role in the first steps of the reverse cholesterol
transport pathway by mediating lipid efflux from macrophages. Previously, it was …

In atherosclerosis, macrophages are important for intracellular lipid accumulation and foam
cell formation. Monocytes respond to chemotactic factors, cytokines, and macrophage …

Background c-Kit is a receptor tyrosine kinase present in multiple cell types, including
vascular smooth muscle cells (SMC). However, little is known about how c-Kit influences …

Aims Delayed lipoprotein clearance is associated with atherosclerosis. This study examined
whether chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnoea (OSA) …

Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and responsible for catalyzing
lipolysis of triglycerides in lipoproteins. LPL is produced mainly in adipose tissue, skeletal …

An initial step in reverse cholesterol transport is the movement of unesterified cholesterol
from peripheral cells to high-density lipoproteins (HDLs). This transfer usually occurs in …