Exploiting the folate receptor α in oncology
Folate receptor α (FRα) came into focus as an anticancer target many decades after the
successful development of drugs targeting intracellular folate metabolism, such as …
successful development of drugs targeting intracellular folate metabolism, such as …
Progress in tumor-associated macrophage (TAM)-targeted therapeutics
C Ngambenjawong, HH Gustafson, SH Pun - Advanced drug delivery …, 2017 - Elsevier
As an essential innate immune population for maintaining body homeostasis and warding
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …
Advances in targeting the folate receptor in the treatment/imaging of cancers
M Fernández, F Javaid, V Chudasama - Chemical science, 2018 - pubs.rsc.org
The folate receptor (FR) is a recognised biomarker for tumour cells due to its overexpression
on a large number of tumours. Consequently, the FR has been exploited by many diagnostic …
on a large number of tumours. Consequently, the FR has been exploited by many diagnostic …
Flow cytometric analysis of myeloid cells in human blood, bronchoalveolar lavage, and lung tissues
YRA Yu, DF Hotten, Y Malakhau, E Volker… - American journal of …, 2016 - atsjournals.org
Clear identification of specific cell populations by flow cytometry is important to understand
functional roles. A well-defined flow cytometry panel for myeloid cells in human …
functional roles. A well-defined flow cytometry panel for myeloid cells in human …
Smart fluorescent probes for imaging macrophage activity
A Fernández, M Vendrell - Chemical Society Reviews, 2016 - pubs.rsc.org
Macrophages are multi-functional immune cells with key roles in host defense and tissue
remodelling. The broad array of macrophage functions has prompted the development of …
remodelling. The broad array of macrophage functions has prompted the development of …
Cyanine conjugate‐based biomedical imaging probes
Cyanine is a class of fluorescent dye with meritorious fluorescence properties and has
motivated numerous researchers to explore its imaging capabilities by miscellaneous …
motivated numerous researchers to explore its imaging capabilities by miscellaneous …
Molecular imaging of chemokine-like receptor 1 (CMKLR1) in experimental acute lung injury
PZ Mannes, CE Barnes, J Biermann… - Proceedings of the …, 2023 - National Acad Sciences
The lack of techniques for noninvasive imaging of inflammation has challenged precision
medicine management of acute respiratory distress syndrome (ARDS). Here, we determined …
medicine management of acute respiratory distress syndrome (ARDS). Here, we determined …
The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis
DMSH Chandrupatla, CFM Molthoff… - Drug Delivery and …, 2019 - Springer
Macrophages play a key role in the pathophysiology of rheumatoid arthritis (RA). Notably,
positive correlations have been reported between synovial macrophage infiltration and …
positive correlations have been reported between synovial macrophage infiltration and …
[HTML][HTML] Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein
ER stress in type II alveolar epithelial cells (AECs) is common in idiopathic pulmonary
fibrosis (IPF), but the contribution of ER stress to lung fibrosis is poorly understood. We found …
fibrosis (IPF), but the contribution of ER stress to lung fibrosis is poorly understood. We found …
Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
BW Richmond, RM Brucker, W Han, RH Du… - Nature …, 2016 - nature.com
Mechanisms driving persistent airway inflammation in chronic obstructive pulmonary
disease (COPD) are incompletely understood. As secretory immunoglobulin A (SIgA) …
disease (COPD) are incompletely understood. As secretory immunoglobulin A (SIgA) …