Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy
characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and …

Severe hemorrhage has posed a serious threat to the health and even life of civilian and
military populations and brought serious economic losses. Consequently, it is imperative to …

The endothelium acts as the barrier that prevents circulating lipids such as lipoproteins and
fatty acids into the arterial wall; it also regulates normal functioning in the circulatory system …

By its strategic position at the interface between blood and tissues, endothelial cells control
blood fluidity and continued tissue perfusion while simultaneously they direct inflammatory …

Four decades have passed since the first discovery of collagen IV by Kefalides in 1966.
Since then collagen IV has been investigated extensively by a large number of research …

We have determined the crystal structure of a complex between the I domain of integrin
α2β1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops …

We have previously assigned an integrin α 2 β 1-recognition site in collagen I to the
sequence, GFOGERGVEGPOGPA (O= Hyp), corresponding to residues 502–516 of the α 1 …

Platelet adhesion on and activation by components of the extracellular matrix are crucial to
arrest post-traumatic bleeding, but can also harm tissue by occluding diseased vessels …

Collagens represent up to 40% of the total protein of the vessel wall, forming an insoluble
scaffold which is essential for tissue integrity and which provides a surface for the …

Hemostat has been a crucial focus since human body is unable to control massive blood
loss, and collagen proves to be an effective hemostat in previous studies. In this study …