Abstract Development of novel therapies for central nervous system (CNS) disorders has
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …

Neurodevelopmental disorders arise due to various risk factors that can perturb different
stages of brain development, and a combinatorial impact of these risk factors programs the …

Teratoma, due to its remarkable ability to differentiate into multiple cell lineages, is a
valuable model for studying human embryonic development. The similarity of the gene …

The brain is a complex computing system composed of a multitude of interacting neurons.
The computational outputs of this system determine the behavior and perception of every …

The brain is the central hub of the entire nervous system. Its development is a lifelong
process guided by a genetic blueprint. Understanding how genes influence brain …

The development of highly parallel and affordable high-throughput single-cell
transcriptomics technologies has revolutionized our understanding of brain complexity …

The hypothalamic–pituitary axis is central to the functioning of the neuroendocrine system
and essential for regulating physiological and behavioral homeostasis and coordinating …

It has long been thought that the functional identity of mammalian brain neurons is
programmed during development and remains stable throughout adult life; however, certain …

Astrocytes are a highly abundant cell type in the brain and spinal cord. Like neurons,
astrocytes can be molecularly and functionally distinct to fulfill specialized roles. Recent …

Mental illnesses arise from dysfunction in the brain. Although numerous extraneural factors
influence these illnesses, ultimately, it is the science of the brain that will lead to novel …