Recombinant adenovirus (rAd) and recombinant adeno-associated virus (rAAV) are among
the most extensively used vectors in gene therapy studies to date. These two vectors share …

Human adenoviral (HAd) vectors have demonstrated great potential as vaccine vectors.
Preclinical and clinical studies have demonstrated the feasibility of vector design, robust …

Mucosal vaccination is proving to be one of the greatest challenges in modern vaccine
development. Although highly beneficial for achieving protective immunity, the induction of …

Vaccines are the most effective and inexpensive prophylactic tool in veterinary medicine.
Ideally, vaccines should induce a lifelong protective immunity against the target pathogen …

Bovine herpesvirus-1 (BHV-1) is a major cause of respiratory tract diseases in cattle.
Vaccination of cattle against BHV-1 is a high priority. A major concern of currently modified …

Peste des petits ruminants virus (PPRV) is a virus that mainly infects goats and sheep
causing significant economic loss in Africa and Asia, but also posing a serious threat to …

Over the past 100 years, animal infectious disease research has played a crucial role in the
development of human vaccines. In fact, many of today's vaccines are based on utilizing …

The immunogenicity of adenovirus (Ad) vectors is enhanced by virus-specific memory
immune responses present in most individuals as a result of past exposure to these …

Replication-defective human adenoviruses type 5 (HAd5) expressing the bovine
herpesvirus type 1 (BHV-1) glycoprotein gC or gD under the control of the human …

The ability of two soluble formulations, namely chitosan and glycol chitosan, when used as
an intranasal adjuvant, to improve the immunogenicity of an intranasal human adenovirus …