Thieno [2, 3-d] pyrimidine as a promising scaffold in medicinal chemistry: Recent advances
EMH Ali, MS Abdel-Maksoud, CH Oh - Bioorganic & medicinal chemistry, 2019 - Elsevier
Thienopyrimidine scaffold is a fused heterocyclic ring system that structurally can be
considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres …
considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres …
A review on synthesis and biological activities of D-ring modified pregnenolone
A Iqbal, T Siddiqui - Steroids, 2021 - Elsevier
Steroids are polycyclic compounds and are broadly exist in the natural world and display
various biological activities. Many steroidal compounds have been used as traditional …
various biological activities. Many steroidal compounds have been used as traditional …
[HTML][HTML] Basic ionic liquids for catalysis: the road to greater stability
Basic ionic liquids can replace organic or inorganic bases in a wide range of reactions. In
this minireview the synthesis of homogeneous and heterogeneous basic ionic liquids and …
this minireview the synthesis of homogeneous and heterogeneous basic ionic liquids and …
Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR
RR Khattab, AK Alshamari, AA Hassan… - Journal of enzyme …, 2021 - Taylor & Francis
In the current study, new thienopyrimidine conjugates bearing 1, 2, 3-triazole core and
different sugar moieties have been designed and synthesized by Cu (I)-catalysed click …
different sugar moieties have been designed and synthesized by Cu (I)-catalysed click …
Synthesis, Antifungal Ergosterol Inhibition, Antibiofilm Activities, and Molecular Docking on β-Tubulin and Sterol 14-Alpha Demethylase along with DFT-Based …
NC Desai, AG Khasiya, DJ Jadeja, JD Monapara… - ACS …, 2023 - ACS Publications
Multidrug-resistant fungal infections have become much more common in recent years,
especially in immune-compromised patients. Therefore, researchers and pharmaceutical …
especially in immune-compromised patients. Therefore, researchers and pharmaceutical …
Synthesis, antifungal evaluation, and molecular docking studies of steroidal thiazolopyrimidines
A series of steroidal thiazolopyrimidine derivatives were developed and evaluated for their
antifungal properties against Candida species using steroid as the basic skeleton and a …
antifungal properties against Candida species using steroid as the basic skeleton and a …
[HTML][HTML] Current research on anti-breast cancer synthetic compounds
J Liu, B Ming, GH Gong, D Wang, GL Bao, LJ Yu - RSC advances, 2018 - pubs.rsc.org
Breast cancer (BC) is the most common cancer for females and its incidence tends to
increase year by year. Currently, the backbone of therapy for BC is mainly chemotherapy …
increase year by year. Currently, the backbone of therapy for BC is mainly chemotherapy …
Synthesis and evaluation of novel D-ring substituted steroidal pyrazolines as potential anti-inflammatory agents
X Cai, S Zhao, D Cai, J Zheng, Z Zhu, D Wei, Z Zheng… - Steroids, 2019 - Elsevier
To identify new potential anti-inflammatory agents, a number of novel steroidal derivatives
with nitrogen heterocyclic side chains 4a-4l were synthesized and evaluated for their anti …
with nitrogen heterocyclic side chains 4a-4l were synthesized and evaluated for their anti …
Synthesis, anticancer activity and molecular docking of new triazolo[4,5-d]pyrimidines based thienopyrimidine system and their derived N-glycosides and …
RR Khattab, AA Hassan, DA A. Osman… - … Nucleotides & Nucleic …, 2021 - Taylor & Francis
A series of new substituted triazolo [4, 5-d] pyrimidine derivatives linked to thienopyrimidine
ring system were prepared as a hybrid heterocyclic systems, as possible nucleobases …
ring system were prepared as a hybrid heterocyclic systems, as possible nucleobases …
Heterocyclic steroids: Synthetic routes and biological characteristics of steroidal fused bicyclic pyrimidines
KM Elattar, A El‐Mekabaty - Journal of Heterocyclic Chemistry, 2021 - Wiley Online Library
Natural steroids are characterized as a vital class of compounds, a type of secondary
metabolites and components of cell membranes that widely accessible in plants or animals …
metabolites and components of cell membranes that widely accessible in plants or animals …