Cancer risk is modulated by hereditary and somatic mutations, exposures, age, sex, and
gender. The mechanisms by which sex and gender work alone and in combination with …

Sex differences are present across multiple non-reproductive organ cancers, with male
individuals generally experiencing higher incidence of cancer with poorer outcomes …

Glioblastoma (GBM) is a hypoxic and" immune-cold" tumor containing rich stromal signaling
molecules and cell populations, such as proteases and immunosuppressive tumor …

Glioma is a type of aggressive and incurable brain tumor. Patients with glioma are highly
resistant to all types of therapies, including immunotherapies. Epigenetic reprogramming is …

Melanoma incidence and mortality rates are historically higher for men than women.
Although emerging studies have highlighted tumorigenic roles for the male sex hormone …

Background Glioblastoma (GBM) is a highly malignant brain tumor that affects men more
often than women. In addition, the former shows a poorer survival prognosis. To date, the …

Glioblastoma is the most common and aggressive primary brain tumor, characterized by a
highly complex and heterogeneous tumor immune microenvironment (TIME). In this review …

Emerging evidence in preclinical models demonstrates that antitumor immunity is not
equivalent between males and females. However, more investigation in patients and across …

The immune system plays critical roles in regulating tumor progression. However, despite
established differences in male and female immune cell function, our appreciation of sex as …

An important aspect of the neuromodulatory and neuroprotective actions exerted by
neuroactive steroids is that they are sex-specific, as determined by the sexually dimorphic …