The complex interplay between chronic inflammation, the microbiome, and cancer: understanding disease progression and what we can do to prevent it
Cancer is a multifaceted condition, in which a senescent cell begins dividing in an irregular
manner due to various factors such as DNA damage, growth factors and inflammation …
manner due to various factors such as DNA damage, growth factors and inflammation …
Synaptopodin-2: A potential tumor suppressor
Z Zheng, Y Song - Cancer Cell International, 2023 - Springer
Initially identified as an actin-binding protein containing a PSD95-DLG-ZO1 Domain (PZD
domain), Synaptopodin 2 (SYNPO2) has long been considered a structural protein …
domain), Synaptopodin 2 (SYNPO2) has long been considered a structural protein …
Clinical presentation and proteomic signature of patients with TANGO2 mutations
Abstract Transport And Golgi Organization protein 2 (TANGO2) deficiency has recently been
identified as a rare metabolic disorder with a distinct clinical and biochemical phenotype of …
identified as a rare metabolic disorder with a distinct clinical and biochemical phenotype of …
[HTML][HTML] Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell …
Abstract Synaptopodin-2 (Synpo2), an actin-binding protein and invasive cancer biomarker,
induces formation of complex stress fiber networks in the cell body and promotes PC3 …
induces formation of complex stress fiber networks in the cell body and promotes PC3 …
Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion
The molecular chaperone Hsp90 is overexpressed in prostate cancer (PCa) and is
responsible for the folding, stabilization and maturation of multiple oncoproteins, which are …
responsible for the folding, stabilization and maturation of multiple oncoproteins, which are …
Synaptopodin-2 plays an important role in the metastasis of breast cancer via PI3K/Akt/mTOR pathway
E Xia, X Zhou, A Bhandari, X Zhang… - Cancer management …, 2018 - Taylor & Francis
Introduction Synaptopodin 2 (SYNPO2) is a functioning protein. It has been detected in
many malignancies. But the relation between SYNPO2 and breast cancer (BC) is unclear …
many malignancies. But the relation between SYNPO2 and breast cancer (BC) is unclear …
Synaptopodin-2 promotes hepatocellular carcinoma metastasis via calcineurin-induced nuclear-cytoplasmic translocation
J Gao, HP Zhang, YH Sun, WZ Guo, J Li, HW Tang… - Cancer letters, 2020 - Elsevier
Hepatocellular carcinoma (HCC), a type of malignant liver tumor, has a grim prognosis. As a
functional protein, synaptopodin-2 (SYNPO2) has been associated with malignancy; …
functional protein, synaptopodin-2 (SYNPO2) has been associated with malignancy; …
Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress
K Lohanadan, S Molt, F Dierck… - Experimental Cell …, 2021 - Elsevier
Protein homeostasis (proteostasis) in multicellular organisms depends on the maintenance
of force-bearing and force-generating cellular structures. Within myofibrillar Z-discs of …
of force-bearing and force-generating cellular structures. Within myofibrillar Z-discs of …
SYNPO2 upregulation is an unfavorable prognostic factor for nasopharyngeal carcinoma patients
Nasopharyngeal carcinoma (NPC) is the most common malignant neoplasm of the
nasopharynx. Despite improvements in the clinical treatment strategies for NPC, NPC …
nasopharynx. Despite improvements in the clinical treatment strategies for NPC, NPC …
[HTML][HTML] Recessive mutations in SYNPO2 as a candidate of monogenic nephrotic syndrome
Y Mao, R Schneider, PFM van der Ven… - Kidney International …, 2021 - Elsevier
Introduction Most of the approximately 60 genes that if mutated cause steroid resistant
nephrotic syndrome (SRNS) are highly expressed in the glomerular podocyte, rendering …
nephrotic syndrome (SRNS) are highly expressed in the glomerular podocyte, rendering …