Bronchodilators are central in the treatment of of airways disorders. They are the mainstay of
the current management of chronic obstructive pulmonary disease (COPD) and are critical in …

It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

Tumor immunotherapy as a new tumor therapy has been intensively studied and reported.
However, the expected utilization and therapeutic effects have not been achieved due to the …

Airway smooth muscle (ASM) plays a key role in bronchomotor tone, as well as in structural
remodeling of the bronchial wall. Therefore, ASM contraction and proliferation significantly …

Multiple pulmonary conditions are characterized by an abnormal misbalance between
various tissue components, for example, an increase in the fibrous connective tissue and …

Rationale: An asthma-like airway phenotype has been described in people with cystic
fibrosis (CF). Whether these findings are directly caused by loss of CF transmembrane …

Maintenance of blood oxygen saturation dictates supplemental oxygen administration to
premature infants, but hyperoxia predisposes survivors to respiratory diseases such as …

Asthma is defined as chronic inflammation of the airways and is characterized by airway
remodeling, hyperresponsiveness, and acute bronchoconstriction of airway smooth muscle …

The clinical need for novel bronchodilators for the treatment of bronchoconstrictive diseases
remains a major medical issue. Modulation of airway smooth muscle (ASM) chloride via …