There is no single source of compiled data on symptoms experienced by patients with
chronic obstructive pulmonary disease (COPD) when awake and active throughout the day …

Background Combining two long-acting bronchodilators with complementary mechanisms of
action may provide treatment benefits to patients with chronic obstructive pulmonary disease …

Chronic obstructive pulmonary disease (COPD) is associated with high morbidity and
mortality. COPD is typified by persistent, progressive airflow limitation and a range of …

Background Ideally, treatment recommendations for maintenance therapy-naïve patients
with COPD should be based on studies conducted specifically in this population. We have …

Background COPD is associated with nighttime respiratory symptoms, poor sleep quality,
and increased risk of nocturnal death. Overnight deterioration of inspiratory capacity (IC) and …

Purpose To assess whether night-time increases in mechanical loading negatively impact
respiratory muscle function in COPD and whether compensatory increases in inspiratory …

This observational study assessed the relationship between nighttime, early-morning and
daytime chronic obstructive pulmonary disease (COPD) symptoms and exacerbations and …

Background Cough and sputum are troublesome symptoms in chronic obstructive
pulmonary disease (COPD) and are associated with adverse outcomes. The efficacy of …

Background The morning tends to be the most difficult time of day for many patients with
chronic obstructive pulmonary disease (COPD) when symptoms can limit one's ability to …

Co-administration of a long-acting β2-agonist and a long acting muscarinic antagonist
produces superior bronchodilation compared with their individual effects. Our preclinical …