DNA pooling is a practical way to reduce the cost of large-scale association studies to
identify susceptibility loci for common diseases. Pooling allows allele frequencies in groups …

The large number of single nucleotide polymorphism (SNP) markers available in the public
databases makes studies of association and fine mapping of disease loci very practical. To …

Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the
gene encoding fetuin. Background Vascular calcification is common among end-stage renal …

Disturbed circadian rhythms have been observed in seasonal affective disorder (SAD). The
aim of this study was to further investigate this connection, and to test for potential …

The haemoglobinopathies refer to a diverse group of inherited disorders characterized by a
reduced synthesis of one or more globin chains (thalassaemias) or the synthesis of a …

Variation in memory performance is to a large extent explained by genes. In the prefrontal
cortex, the catechol O-methyltransferase (COMT) gene is essential in the metabolic …

BACKGROUND: Visfatin, also known as pre–B-cell colony–enhancing factor 1 (PBEF-1),
recently was shown to be secreted from adipocytes and have insulin-mimetic properties in …

DNA sequencing has markedly changed the nature of biomedical research, identifying
millions of polymorphisms along the human genome that now require further analysis to …

Multiple sclerosis (MS) is a T-cell-mediated disease of the central nervous system,
characterized by damage to myelin and axons, resulting in progressive neurological …

Adiponectin in renal disease: Relationship to phenotype and genetic variation in the gene
encoding adiponectin. Background The prevalence of cardiovascular disease (CVD) and …