The Golgi apparatus plays a central role in normal cell physiology by promoting cell survival,
facilitating proliferation, and enabling cell-cell communication and migration. These roles …

In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an
intriguing subject of study for their complex structural characteristics, their finely regulated …

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for resolving
transcriptional heterogeneity. However, its application to studying cancerous tissues is …

Glasdegib is a Hedgehog pathway inhibitor. This ongoing, open‐label, phase 2 study
(NCT01546038) evaluated glasdegib plus cytarabine/daunorubicin in patients with …

Purpose: This open-label, multicenter, dose-finding, phase Ib study (NCT01546038)
evaluated the safety, pharmacokinetics, pharmacodynamics, and clinical activity of the novel …

Alterations in glycan structures are early signs of malignancy and have recently been
proposed to be in part a driving force behind malignant transformation. Here, we explore …

Acute myeloid leukemia (AML) is an aggressive hematological malignancy and affected
patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of …

Simple Summary Cancer-associated glycosylation changes are widely used as biomarkers
and strongly impact malignancy. However, the clinical significance of the deranged …

Cancer immunotherapy, including the inhibition of immune checkpoints, improves the tumor
immune microenvironment and is an effective tool for cancer therapy. More effective and …

Simple Summary Medulloblastoma is one of the most common types of brain tumors in
children. During and after treatment with surgery, chemotherapy, and/or radiotherapy …