Vitamin D shows a variety of pleiotropic activities which cannot be fully explained by the
stimulation of classic pathway-and vitamin D receptor (VDR)-dependent transcriptional …

The active metabolites of vitamin D3 (D3) and lumisterol (L3) exert a variety of antiaging and
photoprotective effects on the skin. These are achieved through immunomodulation and …

Vitamin D, referring to the two forms, D2 from the diet and D3 primarily derived from
phototransformation in the skin, is a prohormone important in human health. The most …

We have previously described new pathways of vitamin D3 activation by CYP11A1 to
produce a variety of metabolites including 20 (OH) D3 and 20, 23 (OH) 2 D3. These can be …

CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol …

To investigate whether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC)
metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we …

RORα and RORγ are expressed in human skin cells that produce the noncalcemic 20-
hydroxyvitamin D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3] …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

The interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors
(LXRs) were investigated. Molecular docking using crystal structures of the ligand binding …

From earliest development on, the vitamin D receptor (VDR) is expressed in most cells of the
mammalian body. The VDR is a nuclear, ligand-induced transcription factor that regulates in …