[HTML][HTML] Nongenomic activities of vitamin D
MA Żmijewski - Nutrients, 2022 - mdpi.com
Vitamin D shows a variety of pleiotropic activities which cannot be fully explained by the
stimulation of classic pathway-and vitamin D receptor (VDR)-dependent transcriptional …
stimulation of classic pathway-and vitamin D receptor (VDR)-dependent transcriptional …
[HTML][HTML] The impact of vitamin D on skin aging
G Bocheva, RM Slominski, AT Slominski - International Journal of …, 2021 - mdpi.com
The active metabolites of vitamin D3 (D3) and lumisterol (L3) exert a variety of antiaging and
photoprotective effects on the skin. These are achieved through immunomodulation and …
photoprotective effects on the skin. These are achieved through immunomodulation and …
The serum vitamin D metabolome: What we know and what is still to discover
RC Tuckey, CYS Cheng, AT Slominski - The Journal of steroid biochemistry …, 2019 - Elsevier
Vitamin D, referring to the two forms, D2 from the diet and D3 primarily derived from
phototransformation in the skin, is a prohormone important in human health. The most …
phototransformation in the skin, is a prohormone important in human health. The most …
Photoprotective properties of vitamin D and lumisterol hydroxyderivatives
AT Slominski, A Chaiprasongsuk, Z Janjetovic… - Cell biochemistry and …, 2020 - Springer
We have previously described new pathways of vitamin D3 activation by CYP11A1 to
produce a variety of metabolites including 20 (OH) D3 and 20, 23 (OH) 2 D3. These can be …
produce a variety of metabolites including 20 (OH) D3 and 20, 23 (OH) 2 D3. These can be …
Novel activities of CYP11A1 and their potential physiological significance
CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol …
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol …
[HTML][HTML] Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland
AT Slominski, TK Kim, W Li, A Postlethwaite, EW Tieu… - Scientific reports, 2015 - nature.com
To investigate whether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC)
metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we …
metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we …
[HTML][HTML] RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy-and 20, 23-dihydroxyvitamin D
AT Slominski, TK Kim, Y Takeda, Z Janjetovic… - The FASEB …, 2014 - ncbi.nlm.nih.gov
RORα and RORγ are expressed in human skin cells that produce the noncalcemic 20-
hydroxyvitamin D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3] …
hydroxyvitamin D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3] …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
[HTML][HTML] Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)
AT Slominski, TK Kim, S Qayyum, Y Song… - Scientific Reports, 2021 - nature.com
The interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors
(LXRs) were investigated. Molecular docking using crystal structures of the ligand binding …
(LXRs) were investigated. Molecular docking using crystal structures of the ligand binding …
Cytochromes P450 are essential players in the vitamin D signaling system
I Schuster - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2011 - Elsevier
From earliest development on, the vitamin D receptor (VDR) is expressed in most cells of the
mammalian body. The VDR is a nuclear, ligand-induced transcription factor that regulates in …
mammalian body. The VDR is a nuclear, ligand-induced transcription factor that regulates in …