Decades of research in animal models have provided abundant evidence to show that IL-13
is a key TH2 cytokine that directs many of the important features of airway inflammation and …

Periostin is a matricellular protein that has been implicated in many disease states. It
interacts with multiple signaling cascades to modulate the expression of downstream genes …

BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients.
We recently described a distinct subtype of asthma defined by the expression of genes …

Allergic inflammation triggered by exposure of an allergen frequently leads to the onset of
chronic inflammatory diseases such as atopic dermatitis (AD) and bronchial asthma. The …

BACKGROUND: Subepithelial fibrosis is a cardinal feature of bronchial asthma. Collagen I,
III, and V; fibronectin; and tenascin-C are deposited in the lamina reticularis. Extensive …

Matricellular proteins are involved in the crosstalk between cells and their environment and
thus play an important role in allergic and inflammatory reactions. Periostin, a matricellular …

We found for the first time that IL-4 and IL-13, signature type 2 cytokines, are able to induce
periostin expression. We and others have subsequently shown that periostin is highly …

This is the English version of the Clinical Practice Guidelines for the Management of Atopic
Dermatitis 2021. Atopic dermatitis (AD) is a disease characterized by relapsing eczema with …

Abstract IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different
cell types and responsible for a broad range of biology and functions. Physiologically, Th2 …

Chronic obstructive pulmonary disease (COPD) is a debilitating heterogeneous disease
characterised by unregulated proteolytic destruction of lung tissue mediated via a protease …