Antimalarial drug resistance and implications for the WHO global technical strategy

MM Ippolito, KA Moser, JBB Kabuya… - Current epidemiology …, 2021 - Springer
Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …

[HTML][HTML] The molecular basis of antimalarial drug resistance in Plasmodium vivax

LE Buyon, B Elsworth, MT Duraisingh - International Journal for …, 2021 - Elsevier
Plasmodium vivax is the most geographically widespread cause of human malaria and is
responsible for the majority of cases outside of the African continent. While great progress …

Single-cell transcription analysis of Plasmodium vivax blood-stage parasites identifies stage- and species-specific profiles of expression

JM Sa, MV Cannon, RL Caleon, TE Wellems… - PLoS …, 2020 - journals.plos.org
Plasmodium vivax and P. falciparum, the parasites responsible for most human malaria
worldwide, exhibit striking biological differences, which have important clinical …

[HTML][HTML] Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions

MU Ferreira, TN de Sousa, GW Rangel… - International Journal for …, 2021 - Elsevier
Emerging antimalarial drug resistance may undermine current efforts to control and
eliminate Plasmodium vivax, the most geographically widespread yet neglected human …

The host targeting effect of chloroquine in malaria

C Coban - Current opinion in immunology, 2020 - Elsevier
Highlights•Chloroquine/hydroxychloroquine is an old anti-malarial drug belongs to 4-
aminoquinolines.•Chloroquine has additional anti-virus, anti-bacteria, anti-protozoan, anti …

Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia–Pacific region

R Noviyanti, O Miotto, A Barry, J Marfurt, S Siegel… - 2020 - Springer
Abstract The Asia–Pacific region faces formidable challenges in achieving malaria
elimination by the proposed target in 2030. Molecular surveillance of Plasmodium parasites …

Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission

TV Pascini, YJ Jeong, W Huang, ZR Pala, JM Sá… - Nature …, 2022 - nature.com
In mammals, the serine protease plasmin degrades extracellular proteins during blood clot
removal, tissue remodeling, and cell migration. The zymogen plasminogen is activated into …

Novel highly-multiplexed AmpliSeq targeted assay for Plasmodium vivax genetic surveillance use cases at multiple geographical scales

JH Kattenberg, HV Nguyen, HL Nguyen… - Frontiers in Cellular …, 2022 - frontiersin.org
Although the power of genetic surveillance tools has been acknowledged widely, there is an
urgent need in malaria endemic countries for feasible and cost-effective tools to implement …

The changing epidemiology of Plasmodium vivax: Insights from conventional and novel surveillance tools

S Auburn, Q Cheng, J Marfurt, RN Price - PLoS medicine, 2021 - journals.plos.org
The changing epidemiology of Plasmodium vivax: Insights from conventional and novel
surveillance tools | PLOS Medicine Skip to main content Advertisement PLOS Medicine …

Genome-wide functional screening of drug-resistance genes in Plasmodium falciparum

S Iwanaga, R Kubota, T Nishi… - Nature …, 2022 - nature.com
The global spread of drug resistance is a major obstacle to the treatment of Plasmodium
falciparum malaria. The identification of drug-resistance genes is an essential step toward …