Cystic fibrosis (CF), the most common lethal genetic disease in the Caucasian population, is
caused by loss-of-function mutations of the CF transmembrane conductance regulator …

Abstract NEDD4-2 (also known as NEDD4L, neural precursor cell expressed
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …

Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) plays a key role in regulating
food intake and energy expenditure at least in part by its actions in hypothalamic neurons …

The peripheral protein quality control (QC) system removes non-native membrane proteins,
including ΔF508-CFTR, the most common CFTR mutant in cystic fibrosis (CF), from the …

Ion channels (IChs) are transmembrane proteins that selectively drive ions across
membranes. The function of IChs partially relies on their abundance and proper location in …

CFTR is an integral transmembrane glycoprotein and a cAMP-activated Cl− channel.
Mutations in the CFTR gene lead to Cystic Fibrosis (CF)–an autosomal recessive disease …

Golgi-localized cystic fibrosis transmembrane conductance regulator (CFTR)-associated
ligand (CAL) and syntaxin 6 (STX6) regulate the abundance of mature, post-ER CFTR by …

Conformationally defective cystic fibrosis transmembrane conductance regulator (CFTR)
including rescued ΔF508-CFTR is rapidly eliminated from the plasma membrane (PM) even …

Background Cystic fibrosis transmembrane conductance regulator plays a key role in
maintenance of lung fluid homeostasis. Cigarette smoke decreases CFTR expression in the …

In the healthy lung the opportunistic pathogen, Pseudomonas aeruginosa, is rapidly
eliminated by mucociliary clearance, a process that is dependent on the activity of the CFTR …