Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Disruption of mitochondrial function and protein homeostasis plays a central role in aging.
However, how these processes interact and what governs their failure in aging remain …

Metabolism has been studied mainly in cultured cells or at the level of whole tissues or
whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity …

Skeletal muscle is greatly affected by aging, resulting in a loss of metabolic and physical
function. However, the underlying molecular processes and how (lack of) physical activity is …

Mitochondria, which serve as the energy factories of cells, are involved in cell differentiation,
calcium homeostasis, amino acid and fatty acid metabolism and apoptosis. In response to …

Alterations in cellular nicotinamide adenine dinucleotide (NAD+) levels have been observed
in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that …

Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …

Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD+) levels are
hallmarks of skeletal muscle ageing and sarcopenia,–, but it is unclear whether these …

Depletion of nicotinamide adenine dinucleotide (NAD+) is associated with aging and
disease, spurring the study of dietary supplements to replenish NAD+. The catabolism of …