Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Inflammation is a key contributor to both the initiation and progression of tumors, and it can
be triggered by genetic instability within tumors, as well as by lifestyle and dietary factors …

Tumor-derived extracellular vesicle (T-EV) microRNAs have been investigated as promising
biomarkers in clinical diagnosis as well as disease progression monitoring. However, the …

Reactive oxygen species (ROS) originate from diverse sources and regulate multiple
signaling pathways within the cellular environment. Their generation is intricately controlled …

The intestinal microbiota is an important environmental factor implicated in CRC
development. Intriguingly, modulation of DNA methylation by gut microbiota has been …

Abstract Esophageal, colorectal, pancreatic, hepatocellular, and gastric cancer together
impact millions of patients worldwide each year, with high overall mortality rates and are …

The detailed association between tumor DNA methylation, including CpG island
methylation, and tumor immunity is poorly understood. CpG island methylator phenotype …

Ten–eleven translocation protein 1 (TET1) functions as an epigenetic regulatory molecule,
mediating the majority of DNA demethylation, and plays a role in the development of …

Deregulation of ten-eleven Translocation protein 1 (TET1) is commonly reported to induce
imbalances in gene expression and subsequently to colorectal cancer development (CRC) …

Cancers are diseases caused by genetic and non-genetic environmental factors. Epigenetic
alterations, some attributed to non-genetic factors, can lead to cancer development …