Challenges in the diagnosis of Parkinson's disease

E Tolosa, A Garrido, SW Scholz, W Poewe - The Lancet Neurology, 2021 - thelancet.com
Parkinson's disease is the second most common neurodegenerative disease and its
prevalence has been projected to double over the next 30 years. An accurate diagnosis of …

Accuracy of clinical diagnosis of Parkinson disease: a systematic review and meta-analysis

G Rizzo, M Copetti, S Arcuti, D Martino, A Fontana… - Neurology, 2016 - AAN Enterprises
Objective: To evaluate the diagnostic accuracy of clinical diagnosis of Parkinson disease
(PD) reported in the last 25 years by a systematic review and meta-analysis. Methods: We …

Detection of neuron-derived pathological α-synuclein in blood

A Kluge, J Bunk, E Schaeffer, A Drobny, W Xiang… - Brain, 2022 - academic.oup.com
To date, no reliable clinically applicable biomarker has been established for Parkinson's
disease. Our results indicate that a long anticipated blood test for Parkinson's disease may …

Current and projected future economic burden of Parkinson's disease in the US

W Yang, JL Hamilton, C Kopil, JC Beck… - npj Parkinson's …, 2020 - nature.com
Parkinson's disease (PD) is one of the world's fastest growing neurological disorders. Much
is unknown about PD-associated economic burdens in the United States (US) and other …

[HTML][HTML] Toward clinical digital phenotyping: a timely opportunity to consider purpose, quality, and safety

K Huckvale, S Venkatesh, H Christensen - NPJ digital medicine, 2019 - nature.com
The use of data generated passively by personal electronic devices, such as smartphones,
to measure human function in health and disease has generated significant research …

Diabetes medications and risk of Parkinson's disease: a cohort study of patients with diabetes

R Brauer, L Wei, T Ma, D Athauda, C Girges… - Brain, 2020 - academic.oup.com
The elevated risk of Parkinson's disease in patients with diabetes might be mitigated
depending on the type of drugs prescribed to treat diabetes. Population data for risk of …

Dementia with Lewy bodies: an update and outlook

TF Outeiro, DJ Koss, D Erskine, L Walker… - Molecular …, 2019 - Springer
Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder
producing progressive cognitive decline that interferes with normal life and daily activities …

α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy

S Dutta, S Hornung, A Kruayatidee, KN Maina… - Acta …, 2021 - Springer
The diagnosis of Parkinson's disease (PD) and atypical parkinsonian syndromes is difficult
due to the lack of reliable, easily accessible biomarkers. Multiple system atrophy (MSA) is a …

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

M Chin-Chan, J Navarro-Yepes… - Frontiers in cellular …, 2015 - frontiersin.org
Neurodegenerative diseases including Alzheimer (AD) and Parkinson (PD) have attracted
attention in last decades due to their high incidence worldwide. The etiology of these …

Epidemiology of Parkinson's disease

OB Tysnes, A Storstein - Journal of neural transmission, 2017 - Springer
Parkinson's disease (PD) affects 1–2 per 1000 of the population at any time. PD prevalence
is increasing with age and PD affects 1% of the population above 60 years. The main …