Nanobodies: next generation of cancer diagnostics and therapeutics

EY Yang, K Shah - Frontiers in Oncology, 2020 - frontiersin.org
The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

The development of human serum albumin-based drugs and relevant fusion proteins for cancer therapy

H Tao, R Wang, W Sheng, Y Zhen - International journal of biological …, 2021 - Elsevier
Human serum albumin (HSA)-based therapeutics have attracted tremendous attention in the
development of anticancer agents. The versatile properties of HSA make HSA-based …

A potent neutralizing nanobody against SARS‐CoV‐2 with inhaled delivery potential

J Gai, L Ma, G Li, M Zhu, P Qiao, X Li, H Zhang… - MedComm, 2021 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has become a serious
burden on global public health. Although therapeutic drugs against COVID‐19 have been …

Ce-MOF@ Au-Based Electrochemical Immunosensor for Apolipoprotein A1 Detection Using Nanobody Technology

B Sun, G Li, Y Wu, J Gai, M Zhu, W Ji… - … Applied Materials & …, 2024 - ACS Publications
Apolipoprotein A1 (Apo-A1) is a well-recognized biomarker in tissues, closely associated
with cardiovascular diseases such as atherosclerosis, coronary artery disease, and heart …

Tumour inhibitory activity on pancreatic cancer by bispecific nanobody targeting PD-L1 and CXCR4

S Hao, S Xu, L Li, Y Li, M Zhao, J Chen, S Zhu, Y Xie… - BMC cancer, 2022 - Springer
Background: Antibodies and derivative drugs targeting immune checkpoints have been
approved for the treatment of several malignancies, but there are fewer responses in …

Emerging landscape of nanobodies and their neutralizing applications against SARS-CoV-2 virus

X Feng, H Wang - ACS Pharmacology & Translational Science, 2023 - ACS Publications
The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the
coronavirus disease 2019 (COVID-19) has significantly altered people's way of life. Despite …

Advances in Metabolic Engineering of Pichia pastoris Strains as Powerful Cell Factories

J Zha, D Liu, J Ren, Z Liu, X Wu - Journal of Fungi, 2023 - mdpi.com
Pichia pastoris is the most widely used microorganism for the production of secreted
industrial proteins and therapeutic proteins. Recently, this yeast has been repurposed as a …

Recent advancements in fusion protein technologies in oncotherapy: A review

T Mahmood, A Shahbaz, N Hussain, R Ali… - International Journal of …, 2023 - Elsevier
Cancer is a complicated, adaptable, and heterogeneous disease caused by a wide variety
of genetic changes that might impair ability of cells to function normally. The majority of the …

[HTML][HTML] Strategies for developing PD-1 inhibitors and future directions

W Chen, Y Huang, W Pan, M Xu, L Chen - Biochemical Pharmacology, 2022 - Elsevier
Abstract PD-L1/PD-1 signaling pathway is unarguably the hottest target for developing
therapeutics against various types of cancers. With elucidation of crystal structure of PD …

Emerging applications of nanobodies in cancer therapy

RM Awad, F Meeus, H Ceuppens, T Ertveldt… - International review of …, 2022 - Elsevier
Cancer is a heterogeneous disease, requiring treatment tailored to the unique phenotype of
the patient's tumor. Monoclonal antibodies (mAbs) and variants thereof have enabled …