We conducted a systematic review to determine variability in how the criteria of the frailty
phenotype (grip strength, weight loss, exhaustion, walking speed, physical activity) were …

Frailty is a complex of symptoms that is characterized by impaired stress tolerance due to a
decline in the functionality of different organs. Due to its multifactorial aetiology, several …

Aging research has been very successful at identifying signaling pathways and
evolutionarily conserved genes that extend lifespan with the assumption that an increase in …

Recurrent hypoglycemia is common in older people with diabetes and is likely to be less
recognized and under reported by patients and health care professionals. Hypoglycemia in …

Background The severe burden imposed by frailty and disability in old age is a major
challenge for healthcare systems in low-and middle-income countries alike. The current …

BACKGROUND Frailty has been suggested as a construct for oncologists to consider in
treating older cancer patients. Therefore, the authors assessed the potential of creating a …

Objectives: Aging with HIV is associated with multisystem vulnerability that might be well
characterized by frailty. We sought to construct a frailty index based on health deficit …

Objectives Frailty is typically assessed in older populations. Identifying frailty in adults aged
under 60 years may also have value, if it supports the delivery of timely care. We sought to …

Mechanisms that control aging are important yet poorly defined. To discover longevity
control genes, we performed a forward genetic screen for delayed reproductive aging in C …

When people age their mortality rate increases exponentially, following Gompertz's law.
Even so, individuals do not die from old age. Instead, they accumulate age-related illnesses …